Content Warning: This article discusses opioids, overdoses, and substance-related harms. Nitazenes are a highly potent class of synthetic opioids often mixed—unknown to users— into other drugs. They pose extreme overdose risk, can be difficult to detect on standard tests, and may require multiple naloxone doses. With commentary from Subject Matter Expert Arun Gupta, MD

Critics continue to question substance use harm reduction. Advocates persist in fighting for it. But the data is precise: harm reduction saves lives. As patterns of drug use shift and risks increase, strategies such as overdose prevention centers, fentanyl test strips, and naloxone access offer a proven path forward. This isn't theory; it's survival. 

Every year on August 31, people worldwide come together for a cause that is painfully personal to many—International Overdose Awareness Day (IOAD). This day is more than just a date on the calendar; it's a powerful movement. It's an opportunity to grieve, remember, educate, and, most importantly, spark change.